SPM Active™ 60 Capsules (30 Day Supply)

SPM Active™ 60 Capsules (30 Day Supply)

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Specialised Pro-Resolving Mediators.

SPM Active™ has been shown to:

  • Stimulate resolution of inflammation.1
  • Assist unresolved and chronic inflammatory processes by actively helping the body naturally restore homeostasis.2
  • SPM Active™ contains standardised and concentrated specialised proresolving mediators (SPMs) exclusive to Metagenics.

Adults: Take 1 capsule twice daily.


Each capsule contains:

Concentrated fish Omega-3 triglycerides (LIPINOVA-11TG™) 498 mg
Equivalent Eicosapentaenoic acid (EPA) 50 mg
Equivalent Docosahexaenoic acid (DHA) 100 mg

Free from corn, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast, soy protein, starches. Free from artificial colours, sweeteners, flavours. Contains fish.  

SPM Active™ is a specific and targeted approach to facilitate the resolution phase in patients experiencing inflammation which may be failing to resolve in a timely manner.Unresolved inflammation can lead into low-grade, chronic inflammation that may worsen existing disease states, impair recovery and negatively affect healthy ageing.3Chronic disease is an increasing health burden and it is now estimated that 1 in 3 Australians live with at least one chronic inflammatory condition including arthritis and other musculoskeletal disorders, cardiovascular disease and diabetes mellitus.4 These health issues are characterised by inflammatory processes disrupting healing and driving chronic states indicating the need for SPMs to help support healthy resolution outcomes.

SPMs found in SPM Active™ are lipid mediators that occur naturally in the body and have been found in various human tissue (such as the brain, lymph nodes and synovial fluid).5 SPMs orchestrate resolution at the site of inflammation to assist tissue repair, healing, recovery and the return to homeostasis.6 These mediators help to:

  • Activate the resolution phase.
  • Signal to, and recruit certain immune cells and inflammatory mediators.
  • Repair damage and clearance of pathogens.
  • Prevent further pathological inflammation without immunosuppression.7,8

Despite omega-3 EPA and DHA being precursors of SPMs, they do not possess significant pro-resolving properties.9 Metagenics, in collaboration with SPMs experts and world-renowned leaders in the field of resolution physiology, are the first to set the standard for defining SPMs within a therapeutic supplement. Using a refined, patent pending fractionation process, specific SPM fractions are standardised for consistent dosing and therapeutic patient outcomes. The special fraction and ratio is isolated, concentrated and measured for bioactivity to verify the active SPMs 17-HDHA and 18-HEPE. This process is exclusive to Metagenics, providing an inflammation-specific solution that is truly Practitioner-only.

Lipinova™ SPM's is a trademark of SOLUTEX GC.


Australia/AU 2013259503
New Zealand/NZ 702325